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平臺編號：bio-087749
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國際編號：ATCC 20868
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拉丁屬名： Glarea lozoyensis
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規(guī)格：frozen
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用途：ATCC原裝進(jìn)口
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服務(wù)費(fèi)用：
加載中…… - 訂購
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注意事項(xiàng)：僅用于科學(xué)研究或者工業(yè)應(yīng)用等非醫(yī)療目的不可用于人類或動(dòng)物的臨床診斷或治療，非藥用，非食用（產(chǎn)品信息以出庫為準(zhǔn)）
MF517*
Glarea lozoyensis Bills et Pelaez 拉丁名
(ATCC? 20868?) 統(tǒng)一編號
Deposited As Zalerion arboricola Buczacki
Strain Designations 別名 MF5171
Application 用途 Produces antifungal agents
Produces pneumocandin complex
Biosafety Level 生物安全等級 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format 提供形式 frozen
Preceptrol? no
Genome Sequenced Strain Yes
Comments 注釋 Taxonomic revision
Genome sequencing strain (Institute of Microbiology, Chinese Academy of Sciences, China)
Morphology Colonies on PDA are attaining 60-62 mm diam. in 4 weeks. Mature colonies are effuse, with submerged and aerial hyphae, surface hairly, lanose, or funiculose, dull to moderately shiny; colony color is pale pinkish buff.
Medium 培養(yǎng)基 ATCC? Medium 200: YM agar or YM broth
ATCC? Medium 336: Potato dextrose agar (PDA)
ATCC? Medium 337: Potato, dextrose, yeast agar (PDY)
Growth Conditions 生長條件
Temperature 培養(yǎng)溫度: 24°C to 26°C
Atmosphere 需氧情況: Typical aerobic
Sequenced Data 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence
GGTTTCCGTAGGTGAACCTGCGGAAGGATCATTACAGTGTTCCCTGCC
CTCGCGGGTAGAAACGCCCACCCTTGTGTAATATATCATGTTGCTTTG
GCAGGCCGCCCTCGGGCACCGGCTCCGGCCGGGTCGCGCCTGCCAG
AGGACCCCAAACTCTGAATGTTAGTGTCGTCTGAGTACTATATAATAG
TTAAAACTTTCAACAACGGATCTCTTGGTTCTGGCATCGATGAAGAAC
GCAGCGAAATGCGATAAGTAATGTGAATTGCAGAATTCAGTGAATCA
TCGAATCTTTGAACGCACATTGCGCCCCGTGGTATTCCGCGGGGCAT
GCCTGTTCGAGCGTCATTTAAACCAATCCAGCTTGCTGGGTCTTGGGC
TCTCGCCTCCGGGCGGGCCTTAAAATCAGTGGCGGCGCCACCCGGCT
CTAAGCGTAGTAATACTCCTCGCTACAGGGCTCCGGGTGGAGGCTGG
CCAACAACCCCCAATTTTATCAGGTTGACCTCGGATCAGGTAGGGATA
CCCGCTGAACTTAAGCATATCAATA
Morphology Colonies on PDA are attaining 60-62 mm diam. in 4 weeks. Mature colonies are effuse, with submerged and aerial hyphae, surface hairly, lanose, or funiculose, dull to moderately shiny; colony color is pale pinkish buff.Name of DepositorMerck & Co., Inc.
U.S. Patent Number 4,931,352
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Isolation 分離基物 Pond water, Valle del Rio Lozoya, Spain
Cross References
Nucleotide (GenBank) : U33266 Zalerion arboricola pyrroline carboxylate reductase (P5CR) mRNA,
Nucleotide (GenBank) : ALVE00000000 Glarea lozoyensis ATCC 20868, whole genome shotgun sequencing project
References 參考文獻(xiàn) Shinohara C, et al. Gypsetin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. I. Fermentation, isolation, physico-chemical properties and biological activity. J. Antibiot. 47: 163-167, 1994. PubMed: 8150711
Nuber B, et al. Gypsetin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination. J. Antibiot. 47: 168-172, 1994. PubMed: 8150712
Giacobbe RA, et al. Antifungal fermentation product. US Patent 4,931,352 dated Jun 5 1990
Giacobbe RA, et al. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol. US Patent 5,021,341 dated Jun 4 1991
Masurekar PS, et al. Pneumocandins from Zalerion arboricola. II. Modification of productspectrum by mutation and medium manipulation. J. Antibiot. 45: 1867-1874, 1992. PubMed: 1490877
Schwartz RE, et al. Pneumocandins from Zalerion arboricola. I. Discovery and isolation. J. Antibiot. 45: 1853-1866, 1992. PubMed: 1490876
Giacobbe RA, et al. Process for antifungal fermentation product. US Patent 4,968,608 dated Nov 6 1990
Fujimori F, Okuda T. Application of the random amplified polymorphic DNA using the polymerase chain reaction for efficient elimination of duplicate strains in microbial screening I. Fungi. J. Antibiot. 47: 173-182, 1994. PubMed: 8150713
Hensens OD, et al. Pneumocandins from Zalerion arboricola. III. Structure elucidation. J. Antibiot. 45: 1875-1885, 1992. PubMed: 1490878
Schmatz DM, et al. Pneumocandins from Zalerion arboricola. IV. Biological evaluation of natural and semisynthetic pneumocandins for activity against Pneumocystis carinii and Candida species. J. Antibiot. 45: 1886-1891, 1992. PubMed: 1490879
Adefarati AA, et al. Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0 (L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0. J. Antibiot. 45: 1953-1957, 1992. PubMed: 1362720
Bills GF, et al. Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola. Mycol. Res. 103: 179-192, 1999.
Lu P, et al. A gene (pks2) encoding a putative 6-methylsalicylic acid synthase from Glarea lozoyensis. Mol Genet Genomics 273: 207-216, 2005. PubMed: 15800788
Zhang A, et al. Efficient disruption of a polyketide synthase gene ( pks1) required for melanin synthesis through Agrobacterium-mediated transformation of Glarea lozoyensis. Mol Genet Genomics 268: 645-655, 2003. PubMed: 12589439
(ATCC? 20868?) 統(tǒng)一編號
Deposited As Zalerion arboricola Buczacki
Strain Designations 別名 MF5171
Application 用途 Produces antifungal agents
Produces pneumocandin complex
Biosafety Level 生物安全等級 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format 提供形式 frozen
Preceptrol? no
Genome Sequenced Strain Yes
Comments 注釋 Taxonomic revision
Genome sequencing strain (Institute of Microbiology, Chinese Academy of Sciences, China)
Morphology Colonies on PDA are attaining 60-62 mm diam. in 4 weeks. Mature colonies are effuse, with submerged and aerial hyphae, surface hairly, lanose, or funiculose, dull to moderately shiny; colony color is pale pinkish buff.
Medium 培養(yǎng)基 ATCC? Medium 200: YM agar or YM broth
ATCC? Medium 336: Potato dextrose agar (PDA)
ATCC? Medium 337: Potato, dextrose, yeast agar (PDY)
Growth Conditions 生長條件
Temperature 培養(yǎng)溫度: 24°C to 26°C
Atmosphere 需氧情況: Typical aerobic
Sequenced Data 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence
GGTTTCCGTAGGTGAACCTGCGGAAGGATCATTACAGTGTTCCCTGCC
CTCGCGGGTAGAAACGCCCACCCTTGTGTAATATATCATGTTGCTTTG
GCAGGCCGCCCTCGGGCACCGGCTCCGGCCGGGTCGCGCCTGCCAG
AGGACCCCAAACTCTGAATGTTAGTGTCGTCTGAGTACTATATAATAG
TTAAAACTTTCAACAACGGATCTCTTGGTTCTGGCATCGATGAAGAAC
GCAGCGAAATGCGATAAGTAATGTGAATTGCAGAATTCAGTGAATCA
TCGAATCTTTGAACGCACATTGCGCCCCGTGGTATTCCGCGGGGCAT
GCCTGTTCGAGCGTCATTTAAACCAATCCAGCTTGCTGGGTCTTGGGC
TCTCGCCTCCGGGCGGGCCTTAAAATCAGTGGCGGCGCCACCCGGCT
CTAAGCGTAGTAATACTCCTCGCTACAGGGCTCCGGGTGGAGGCTGG
CCAACAACCCCCAATTTTATCAGGTTGACCTCGGATCAGGTAGGGATA
CCCGCTGAACTTAAGCATATCAATA
Morphology Colonies on PDA are attaining 60-62 mm diam. in 4 weeks. Mature colonies are effuse, with submerged and aerial hyphae, surface hairly, lanose, or funiculose, dull to moderately shiny; colony color is pale pinkish buff.Name of DepositorMerck & Co., Inc.
U.S. Patent Number 4,931,352
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Isolation 分離基物 Pond water, Valle del Rio Lozoya, Spain
Cross References
Nucleotide (GenBank) : U33266 Zalerion arboricola pyrroline carboxylate reductase (P5CR) mRNA,
Nucleotide (GenBank) : ALVE00000000 Glarea lozoyensis ATCC 20868, whole genome shotgun sequencing project
References 參考文獻(xiàn) Shinohara C, et al. Gypsetin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. I. Fermentation, isolation, physico-chemical properties and biological activity. J. Antibiot. 47: 163-167, 1994. PubMed: 8150711
Nuber B, et al. Gypsetin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination. J. Antibiot. 47: 168-172, 1994. PubMed: 8150712
Giacobbe RA, et al. Antifungal fermentation product. US Patent 4,931,352 dated Jun 5 1990
Giacobbe RA, et al. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol. US Patent 5,021,341 dated Jun 4 1991
Masurekar PS, et al. Pneumocandins from Zalerion arboricola. II. Modification of productspectrum by mutation and medium manipulation. J. Antibiot. 45: 1867-1874, 1992. PubMed: 1490877
Schwartz RE, et al. Pneumocandins from Zalerion arboricola. I. Discovery and isolation. J. Antibiot. 45: 1853-1866, 1992. PubMed: 1490876
Giacobbe RA, et al. Process for antifungal fermentation product. US Patent 4,968,608 dated Nov 6 1990
Fujimori F, Okuda T. Application of the random amplified polymorphic DNA using the polymerase chain reaction for efficient elimination of duplicate strains in microbial screening I. Fungi. J. Antibiot. 47: 173-182, 1994. PubMed: 8150713
Hensens OD, et al. Pneumocandins from Zalerion arboricola. III. Structure elucidation. J. Antibiot. 45: 1875-1885, 1992. PubMed: 1490878
Schmatz DM, et al. Pneumocandins from Zalerion arboricola. IV. Biological evaluation of natural and semisynthetic pneumocandins for activity against Pneumocystis carinii and Candida species. J. Antibiot. 45: 1886-1891, 1992. PubMed: 1490879
Adefarati AA, et al. Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0 (L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0. J. Antibiot. 45: 1953-1957, 1992. PubMed: 1362720
Bills GF, et al. Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola. Mycol. Res. 103: 179-192, 1999.
Lu P, et al. A gene (pks2) encoding a putative 6-methylsalicylic acid synthase from Glarea lozoyensis. Mol Genet Genomics 273: 207-216, 2005. PubMed: 15800788
Zhang A, et al. Efficient disruption of a polyketide synthase gene ( pks1) required for melanin synthesis through Agrobacterium-mediated transformation of Glarea lozoyensis. Mol Genet Genomics 268: 645-655, 2003. PubMed: 12589439
