Mycobacterium ulcerans 拉丁名 MacCallum et al. (ATCC? 19423?) 統(tǒng)一編號(hào)
Strain Designations 別名 NCTC 10417 [ATCC 14188, DSM 44154, RT, TMC 1617]
Isolation 分離源 Pus from leg ulcer
Biosafety Level生物安全等級(jí) 2
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format 提供形式 frozen
Storage Conditions 保存方法
Frozen 冷凍物 : -80°C or colder
Freeze-Dried 凍干物 : 2°C to 8°C
Live Culture: See Propagation Section
Preceptrol? no
Type Strain 模式菌株 yes
Comments 注釋
This strain demonstrates reduced virulence in mice and does not produce mycolactone.
Medium 培養(yǎng)基 ATCC? Medium 1395: Middlebrook 7H9 broth with ADC enrichment
ATCC? Medium 173: Middlebrook 7H10 agar with Middlebrook OADC enrichment
ATCC? Medium 90: Lowenstein Jenson medium
Growth Conditions
Temperature 培養(yǎng)溫度 : 30°C
Atmosphere 需氧情況 : Aerobic
Name of Depositor 寄存人 NCTC
Special Collection NCRR Contract
Chain of Custody 來源國家 ATCC <-- NCTC <-- G Buckle RT
Isolation 分離源 Pus from leg ulcer
References 參考文獻(xiàn) Bentoucha A, et al. Activities of new macrolides and fluoroquinolones against Mycobacterium ulcerans infection in mice. Antimicrob. Agents Chemother. 45(11): 3109-3112, 2001. PubMed: 11600364
Bonicke R. Identification of mycobacteria by biochemical methods. Bull. Int. Union Tuberc. 32: 13-68, 1962.
Bull. Int. Union Tuberc. 30: 202, 1960.
Dega H, et al. Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice. Antimicrob. Agents Chemother. 46(10): 3193-3196, 2002. PubMed: 12234844
Dega H, et al. Activities of several antimicrobials against Mycobacterium ulcerans infection in mice. Antimicrob. Agents Chemother. 44(9): 2367-2372, 2000. PubMed: 10952581
Fenner, F. The pathogenic behavior of Mycobacterium ulcerans and Mycobacterium balnei in the mouse and the developing chick embryo. Am. Rev. Tuberc. 73(5): 650-673, 1956.
Fenner F. The significance of the incubation period in infectious diseases. Med. J. Aust. 2: 813-818, 1950. PubMed: 14796139
Fenner F, Leach RH. Studies on Mycobacterium ulcerans. I. Serological relationship to other mycobacteria. Aust. J. Exp. Biol. Med. Sci. 30: 1-10, 1952.
Fenner F, Leach RH. Studies on Mycobacterium ulcerans. II. Cross reactivity in guinea pigs sensitized with Mycobacterium ulcerans and other mycobacteriium. Aust. J. Exp. Biol. Med. Sci. 30: 11-20, 1952.
George KM, et al. Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science. 283(5403): 854-857, 1999. PubMed: 9933171
George KM, Pascopella L, Welty DM, Small PL. A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells. Infect. Immun. 68(2): 877-883, 2000. PubMed: 10639458
Lapage SP, et al. Annotations from the FCTC on the list of type and reference strains of bacteria, Sneath and Skerman 1966. Int. J. Syst. Bacteriol. 17: 93-103, 1967.
MacCallum P. A new mycobacterial infection in man. I. Clinical aspects. J. Pathol. Bacteriol. 60: 93-122, 1948.
P Converse, personal communication
Skerman VB, et al. Approved lists of bacterial names. Int J Syst Bacteriol 30: 225-420, 1980.
Sneath PH, Skerman VB. A list of type and reference strains of bacteria. Int. J. Syst. Bacteriol. 16: 1-134, 1966.
Stinear TP, et al. Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J. Bacteriol. 187(5): 1668-1676, 2005. PubMed: 15716437
Cross References
Nucleotide (GenBank) : AJ271681 Mycobacterium ulcerans tlyA gene for putative haemolysin.
Nucleotide (GenBank) : X99217 M.ulcerans internal transcribed spacer between 16S and 23S rRNA, genomic sequence.