ATCC? Number:50998?
Organism: Acanthamoeba polyphaga (Puschkarew) Page
Designations: LNKY-1
Isolation: United Kingdom
Biosafety Level:2
Shipped: frozen
Growth Conditions: ATCCmedium 712: PYGTemperature: 25.0℃ Duration: Axenic
Permits/Forms: In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location.
Classification: KINGDOM: Protozoa
References: 34376: Gao LY, et al. Identification of macrophage-specific infectivity loci (mil) of Legionella pneumophila that are not required for infectivity of protozoa. Infect. Immun. 66: 883-892, 1998. PubMed: 9488371 34901: Harb OS, et al. Heterogeneity in the attachment and uptake mechanisms of the Legionnaires' disease bacterium, Legionella pneumophila, by protozoan hosts. Appl. Environ. Microbiol. 64: 126-132, 1998. PubMed: 9435069 35368: Harb OS, Abu Kwaik Y. Identification of the aspartate-beta-semialdehyde dehydrogenase gene of Legionella pneumophila and characterization of a null mutant. Infect. Immun. 66: 1898-1903, 1998. PubMed: 9573067 35393: Stone BJ, Abu Kwaik Y. Expression of multiple pili by Legionella pneumophila: identification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells. Infect. Immun. 66: 1768-1775, 1998. PubMed: 9529112 51870: Pedersen LL, et al. HtrA homologue of Legionella pneumophila: an indispensable element for intracellular infection of mammalian but not protozoan cells. Infect. Immun. 69: 2569-2579, 2001. PubMed: 11254621 56504: Viswanathan VK, et al. The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element. Infect. Immun. 70: 1842-1852, 2002. PubMed: 11895946 70515: Gao L-Y, et al. Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cells. Microb. Pathog. 27: 273-287, 1999. PubMed: 10545255 70558: Gao LY, et al. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa. Infect. Immun. 65: 4738-4746, 1997. PubMed: 9353059 70559: Molmeret M, et al. The C-terminus of IcmT is essential for pore formation and for intracellular trafficking of Legionella pneumophila within Acanthamoeba polyphaga. Mol. Microbiol. 43: 1139-1150, 2002. PubMed: 11918802 70560: Molmeret M, et al. icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells. Infect. Immun. 70: 69-78, 2002. PubMed: 11748165