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ATCC? Number:50803?
Organism: Giardia intestinalis (Lambl) Alexeieff
Designations: WB clone C6
Isolation: clone of strain WB (ATCC30957), 1983
Depositors: FD Gillin
Biosafety Level:2
Shipped: frozen
Growth Conditions: ATCCmedium 2155: LYI Giardia Medium (filtered)Temperature: 35.0℃ Duration: axenic; anaerobic
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Comments: Excellent cyst-formation under axenic conditions Variable surface antigen  [24148] differential mRNA processing  [49717] Genome sequencing strain
Related Items: purified DNA:ATCC50803D
Cross References: Nucleotide (GenBank) : AACB02000000Giardia lamblia ATCC50803 strain WB C6, whole genome shotgun sequencing project.
Classification: KINGDOM: Archeozoa
References:  23858: Aley SB, et al. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides.  Infect. Immun. 62: 5397-5403, 1994. PubMed: 7960119 23882: Reiner DS, et al. A lipoprotein-cholesterol-albumin serum substitute stimulates Giardia lamblia encystation vesicle formation.  J. Eukaryot. Microbiol. 42: 622-627, 1995. PubMed: 7581338 24148: Aley SB, Gillin FD. Giardia lamblia: post-translational processing and status of exposed cysteine residues in TSA 417, a variable surface antigen.  Exp. Parasitol. 77: 295-305, 1993. PubMed: 8224085 24214: Reiner DS, et al. Giardia lamblia: absence of cyst antigens and reduced secretory vesicle formation and bile salt uptake in an encystation-deficient subline.  Exp. Parasitol. 77: 461-472, 1993. PubMed: 7504633 33119: Das S, Gillin FD. Giardia lamblia: increased UDP-N-acetyl-D-glucosamine and N-acetyl-D-galactosamine transferase activities during encystation.  Exp. Parasitol. 83: 19-29, 1996. PubMed: 8654548 44639: Knodler LA, et al. Novel protein-disulfide isomerases from the early-diverging protist Giardia lamblia.  J. Biol. Chem. 274: 29805-29811, 1999. PubMed: 10514458 49635: Eckmann L, et al. Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia.  J. Immunol. 164: 1478-1487, 2000. PubMed: 10640765 49717: Que X, et al. Developmentally regulated transcripts and evidence of differential mRNA processing in Giardia lamblia.  Mol. Biochem. Parasitol. 81: 101-110, 1996. PubMed: 8892309 52272: Abel ES, et al. Possible roles of protein kinase A in cell motility and excystation of the early diverging eukaryote Giardia lamblia.  J. Biol. Chem. 276: 10320-10329, 2001. PubMed: 11104758 56522: Marti M, et al. Conformationally correct expression of membrane-anchored Toxoplasma gondii SAG1 in the primitive protozoan Giardia duodenalis.  Infect. Immun. 70: 1014-1016, 2002. PubMed: 11796643 70325: McArthur AG, et al. The evolutionary origins of eukaryotic protein disulfide isomerase domains: new evidence from the Amitochondriate protist Giardia lamblia.  Mol. Biol. Evol. 18: 1455-1463, 2001. PubMed: 11470836 70326: Morrison HG, et al. Giardia lamblia expresses a proteobacterial-like DnaK homolog.  Mol. Biol. Evol. 18: 530-541, 2001. PubMed: 11264404 70327: Ellis JG IV, et al. Potential involvement of extracellular signal-regulated kinase 1 and 2 in encystation of a primitive eukaryote, Giardia lamblia. Stage-specific activation and intracellular localization.  J. Biol. Chem. 278: 1936-1945, 2003. PubMed: 12397063 70387: Ey PL, Darby JM. VSP417-6, a variant-specific surface protein encoded at a sixth locus within the vsp417 gene subfamily of Giardia intestinalis.  Int. J. Parasitol. 32: 425-436, 2002. PubMed: 11849639 70390: Langford TD, et al. Giardia lamblia: identification and characterization of Rab and GDI proteins in a genome survey of the ER to Golgi endomembrane system.  Exp. Parasitol. 101: 13-24, 2002. PubMed: 12243734 70411: Sanchez LB, et al. Cloning and sequencing of an acetyl-CoA synthetase (ADP-forming) gene from the amitochondriate protist, Giardia lamblia.  Gene 233: 225-231, 1999. PubMed: 10375639 70541: Henze K, et al. Unique phylogenetic relationships of glucokinase and glucosephosphate isomerase of the amitochondriate eukaryotes Giardia intestinalis, Spironucleus barkhanus and Trichomonas vaginalis.  Gene 281: 123-131, 2001. PubMed: 11750134 70692: Sun C-H, et al. A novel Myb-related protein involved in transcriptional activation of encystation genes in Giardia lamblia.  Mol. Microbiol. 46: 971-984, 2002. PubMed: 12421304