ATCC? Number:VR-770?
Classification: Retroviridae,Gammaretrovirus,Avian virus group
Agent: Reticuloendotheliosis virus
Strain: T [F]
Depositors: RL Witter
Biosafety Level:2
Shipped: frozen
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Host Organism : chicken embryo fibroblasts; chicken chicken embryo fibroblasts in tissue culture; chicken bone marrow cells; chicken; turkey; quail; duck; other avian species
Incubation : Duration: 8 days
Effect : Yes, in vitro effects: Cytopathic effects (moderate) and immunofluorescent antigen in tissue culture Yes, in vivo effects: Death in animals
Comments : Negative for ALV. The original member of the rel oncogene family, 'v-rel', is found in REV-T. Virus may lose tumorigenicity on tissue culture passage. TC propagated material contains helper viruses.
References : 33877: Thielen GH, et al. Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. J. Natl. Cancer Inst. 37: 731-743, 1966. PubMed: 4289067 33878: Purchase HG, et al. A new group of oncogenic viruses: reticuloendotheliosis, chick syncytial, duck infectious anemia, and spleen necrosis viruses. J. Natl. Cancer Inst. 51: 489-499, 1973. PubMed: 4358134 33880: Witter RL, et al. Peripheral nerve lesions similar to those of Marek's disease in chickens inoculated with reticuloendotheliosis virus. J. Natl. Cancer Inst. 45: 567-577, 1970. PubMed: 5002007