ATCC? Number:VR-659?
Classification: Retrovirus, Avian Type C Retrovirus Group
Agent: Rous sarcoma virus
Strain: RAV-50 [Bryan high titer]
Original Source: chicken
Depositors: W Okazaki, HG Purchase
Biosafety Level:2
Shipped: frozen
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Host Organism : chicken embryo fibroblasts; chicken; many birds and mammals
Incubation : Temperature: 37.0°C Duration: 7 days
Effect : Yes, in vitro effects: Transformation in chicken embryo fibroblasts in tissue culture Yes, tumorigenicity: sarcoma in chicken
Comments : Usually oncogenic in mammals. This strain is a mixture of a defective sarcoma virus (Bryan RSV) and a replication competent helper virus, RAV-50.
References : 33519: Duff RG, Vogt PK. Characteristics of two new avian tumor virus subgroups. Virology 39: 18-30, 1969. PubMed: 4309068 33747: Morgan HR, Traub W. . Natl. Cancer Inst. Monogr. 17: 392, 1964. 33748: Vogt PK. Envelope classification of avian RNA tumor viruses. Bibl. Haematol. 36: 153-167, 1970. PubMed: 4376359 33750: Hanafusa H, Hanafusa T. Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals. Proc. Natl. Acad. Sci. USA 55: 532-538, 1966. PubMed: 4287489