ATCC? Number:VR-63?
Classification: Picornaviridae, Enterovirus, Poliovirus
Agent: Human poliovirus 3 (attenuated) deposited as Poliovirus 3 (attenuated)
Strain: LH
Original Source: Laboratory variant selected from Leon strain at Mk/24 passage level
Depositors: AR Fodor
Biosafety Level:3
Shipped: freeze-dried
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Host Organism : mouse, i. s. inoculation mouse; monkey, i. c. or i. s. inoculation; LLC-MK2 (ATCCCCL-7.1)
Incubation : Duration: 2-4 days
Effect : Yes, in vivo effects: Paralysis
Comments : [The BMBL notes that all laboratory personnel working directly with the agent must have documented polio vaccination or demonstrated serologic evidence of immunity to all three poliovirus types. (CDC/NIH Biosafety in Microbiological and Biomedical Laboratories, 4th ed, 1999 - stock no. 017-040-00547-4)]. Little or no pathogenicity for mice by i.c. route. Produces paralysis irregularly in monkeys.
References : 33725: Li CP, Habel K. Adaptation of Leon strain of poliomyelitis to mice. Proc. Soc. Exp. Biol. Med. 78: 233-238, 1951. PubMed: 14891978 33726: Li CP, Schaeffer M. Further modification of the mouse adapted type III poliomyelitis virus. Proc. Soc. Exp. Biol. Med. 83: 706-708, 1953. PubMed: 13120861