ATCC? Number:VR-236?
Classification: Poxviridae, Leporipoxvirus, Myxoma virus
Agent: Squirrel fibroma virus deposited as Fibroma virus
Strain: Kilham
Original Source: Naturally occurring fibroma of gray squirrels (Sciurus carolinensis), Maryland, 1952
Depositors: L Kilham
Biosafety Level:2
Shipped: frozen
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Host Organism : rabbit kidney cells; monkey kidney cells; monkey rabbit kidney cells; squirrel kidney cells; young woodchuck (Mamorata monax)
Incubation : Duration: 3-7 days
Effect : Yes, in vitro effects: cytopathic effects in primary rabbit kidney cells (The virus causes eventual degeneration of cell monolayer, focal piling of cells occurs during replicatication. Replication of virus may occur without cytopathetic effects in other types of tissue culture cells.)
Comments : The virus will produce lesions in the skin of domestic rabbits, but efforts to pass it serially in rabbits have not been successful. Tumors apperar in 3 days and commence to regress in 6 days. Young woodchucks are usually susceptible (i.d.), and tumors may persist for 6 weeks. Tumors develop in young and in adult infected squirrels in 1 to 2 weeks.
References : 33413: Kilham L, et al. Naturally occurring fibromas of grey squirrels related to Shope's rabbit fibroma. Proc. Soc. Exp. Biol. Med. 82: 298-301, 1953. PubMed: 13037878