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平臺(tái)編號(hào)：bio-131643
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細(xì)胞信息： GIST882
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規(guī)格：1×10?cells/T25培養(yǎng)瓶
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注意事項(xiàng)：僅用于科學(xué)研究或者工業(yè)應(yīng)用等非醫(yī)療目的不可用于人類或動(dòng)物的臨床診斷或治療，非藥用，非食用（產(chǎn)品信息以出庫(kù)為準(zhǔn)）
人胃腸道間質(zhì)瘤細(xì)胞GIST882
細(xì)胞名稱：人胃腸道間質(zhì)瘤細(xì)胞GIST882
產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2
細(xì)胞數(shù)量：1x10^6；1x10^6
保存溫度：37℃；-198℃
運(yùn)輸方式：常溫保溫運(yùn)輸；干冰運(yùn)輸
安全等級(jí)：1
用途限制：僅供科研3類
培養(yǎng)體系：DMEM高糖+10%FBS+1%三抗
培養(yǎng)溫度：37℃
二氧化碳濃度：5%
注釋：人胃腸道間質(zhì)瘤細(xì)胞GIST882取自女性供體。
注釋：倍增時(shí)間34h
基因突變：Homozygous for KIT p.Lys642Glu(c.1924A>G)(PubMed=11526490;PubMed=16077968).
HLA信息
STR信息
參考文獻(xiàn)
PubMed=11526490;DOI=10.1038/sj.onc.1204704
Tuveson D.A.,Willis N.A.,Jacks T.,Griffin J.D.,Singer S.,Fletcher C.D.M.,Fletcher J.A.,Demetri G.D.
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein:biological and clinical implications.
Oncogene 20:5054-5058(2001)
PubMed=16077968;DOI=10.3892/or.14.3.645
Noma K.,Naomoto Y.,Gunduz M.,Matsuoka J.,Yamatsuji T.,Shirakawa Y.,Nobuhisa T.,Okawa T.,Takaoka M.,Tomono Y.,Hiroyuki O.,Gunduz E.,Tanaka N.
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol.Rep.14:645-650(2005)
PubMed=16982758;DOI=10.1158/0008-5472.CAN-06-0165
Bauer S.,Yu L.K.,Demetri G.D.,Fletcher J.A.
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.
Cancer Res.66:9153-9161(2006)
PubMed=19706776;DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T.,Zhang Y.,Wagner A.J.,Grabellus F.,Bradner J.,Taeger G.,Lang H.,Taguchi T.,Schuler M.,Fletcher J.A.,Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling,acetylate HSP90,and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res.69:6941-6950(2009)
產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2
細(xì)胞數(shù)量：1x10^6；1x10^6
保存溫度：37℃；-198℃
運(yùn)輸方式：常溫保溫運(yùn)輸；干冰運(yùn)輸
安全等級(jí)：1
用途限制：僅供科研3類
培養(yǎng)體系：DMEM高糖+10%FBS+1%三抗
培養(yǎng)溫度：37℃
二氧化碳濃度：5%
注釋：人胃腸道間質(zhì)瘤細(xì)胞GIST882取自女性供體。
注釋：倍增時(shí)間34h
基因突變：Homozygous for KIT p.Lys642Glu(c.1924A>G)(PubMed=11526490;PubMed=16077968).
HLA信息
STR信息
參考文獻(xiàn)
PubMed=11526490;DOI=10.1038/sj.onc.1204704
Tuveson D.A.,Willis N.A.,Jacks T.,Griffin J.D.,Singer S.,Fletcher C.D.M.,Fletcher J.A.,Demetri G.D.
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein:biological and clinical implications.
Oncogene 20:5054-5058(2001)
PubMed=16077968;DOI=10.3892/or.14.3.645
Noma K.,Naomoto Y.,Gunduz M.,Matsuoka J.,Yamatsuji T.,Shirakawa Y.,Nobuhisa T.,Okawa T.,Takaoka M.,Tomono Y.,Hiroyuki O.,Gunduz E.,Tanaka N.
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol.Rep.14:645-650(2005)
PubMed=16982758;DOI=10.1158/0008-5472.CAN-06-0165
Bauer S.,Yu L.K.,Demetri G.D.,Fletcher J.A.
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.
Cancer Res.66:9153-9161(2006)
PubMed=19706776;DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T.,Zhang Y.,Wagner A.J.,Grabellus F.,Bradner J.,Taeger G.,Lang H.,Taguchi T.,Schuler M.,Fletcher J.A.,Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling,acetylate HSP90,and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res.69:6941-6950(2009)
